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Integration of monitored variables allows cross vali- dation and artifact rejection, better understanding of pathophysiology and the potential to target therapy. b The shadowed input of only a part of the target. Above all this book would not have been possible without access to the Li- brary of the Sanvenero-Rosselli Foundation in Milan and we are indebted to Riccardo Mazzola for his per- mission and assistance in using all the facilities in that institution. Additionally, the anti- microbial drug markets may be affected by patterns of resis- tance, generally compromising the marketability of older (usually cheaper and narrow-spectrum) drugs and favoring marketability of newer (usually more expensive and broad- spectrum) ones (29).
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