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005 0 Delay (msec) 0. Trials of hGH treatment in the elderly have shown that the hormone is able to reverse these changes (Jorgensen and Christiansen, 1993), but a recent review of world-wide clinical trials of hGH in the elderly was not favourable (Marcus and Hoffman, Page 194 Page 69 пvariations BIBP3226 181 YRLRY-NH2 130 Nasal mucosa, vasoconstriction Neuroblastoma cell lines see SK-N-MC, SMK- KAN and SK-N-BE2 neuroblastoma cells Neurotransmission, NPY in sympathetic 43-8 NOEs 108 Non-adrenergic vasoconstriction 44, 46 Non-insulin dependent diabetes mellitus (NIDDM) 15, 17 Non-linear regression analysis 129 Nonapeptide dimers 142 Noradrenaline NPYergic activity 17,29 neurons 18, 19, 70, 73, 77 Nuclear magnetic resonance (NMR) studies 128 a-Helix 108 compound 56 and 65 138, 139-40 conformation of NPY, Y2 receptor 118 GW1229 148 pentapeptide ligands 135 Nucleus accumbens 16 tractus solitarius (NTS) 7, 8, 9, 61, 62, 63, 76 Obesity 15, 26-8, 169 BAT reduction 22 hypothalamus 17,24 PVN destruction 19 Olfactory bulb 16,61,62,65,66 bulbectomy 78 nuclei, anterior 59, 61, 65 tubercle 65 Opioid peptides 16 Orexigenic effect, NPY 19-20,21 Oriens layer 61 pA2 values 166 Palmitate 89,94 Pancreas 2, 43, 100 Pancreatic polypeptide receptors see PP1Y4 receptors aPP (avian) 107, 127, 128, 148 bPP(bovine) 128 2IbPP 63, 76 Parasympathetic nerve fibres 6 Paraventricularnucleus(PVN) 18,24 diabetic rat 29 feeding behaviour 19,57 obese Zucker rats 27 YlmRNA 68,91 PC 12 cells 10 Pentapeptide dimers, mechanism of binding 150-1 Pentapeptides 129, 133 dimers and multimers 149-51 Peptide YYJPYY Perifornical hypothalamus (PFH) Phaeochromocytoma 49, 169 Pharmacophore hypothesis, design and synthesis non-peptide NPY receptor antagonists 195-200 Phenoxybenzamine 42 Phentolamine 42, 45 Physical exercise 42, 49 Piriform cortex 61 Pithed rats BIBP 3226 effect on NPY 185 SR120819A effects on NPY 166 co-release with NPY 41 level reduction 44 release 6, 42, 46, 47 stimulation of feeding 16 Northern hybridization 91,94, 100 NPYl-12 111 NPYl-24 111 NPYl-35-tyramide NPY2-36 20, 60, 62, 89, 94, 110, 111 i25iNpY2_36 58, 60 NPY3-36 43, 98 NPY4-36 111 NPY13-36 20,25,26, 108, 109, 110, 111, 128, 133, 134, 166 human Yl receptor 89 human Y2 receptor 94 rat brain 59, 60, 62, 75 i25iNpYi3_36 58 NPY18-36 NPY21-36 NPY22-26 NPY25-26 NPY27-36 NPY29-36 NPY32-26 NPY 62,89,94,108, 111 113 111 136 113,117 115 133 analogues centrally truncated conformationally constrained model of active conformations 122 receptor types table 112 108-10 3, 5, 20 antagonists see Antagonists antibody 23, 58 cardiac muscle, actions on 48 half-life 43, 46 immunoreactivity 16,26,42,57 human brain 76-7 19-20 111 rat brain 74, 75 plasma and clearance 42-3 prejunctional regulation 42, 47-8 segments 111, 113 sequence and secondary structure 107-8 systematic scanning in full-length 114в16 113-14 44, 45 116-18 118-19, Index 207 пппппппппппппппппппппппппппппппппппппппппAbbreviation Meaning TN trigeminal neuralgia TNF tumor necrosis factor TNM tumor, node, metastases staging TOEFL Test of English as a Foreign Language tPA tissue plasminogen activator TPP thiamine pyrophosphate TPR total peripheral resistance TRAP tartrate-resistant acid phosphatase TRH thyrotropin-releasing hormone tRNA transfer ribonucleic acid Trp tryptophan TSH thyroid-stimulating hormone TSI thyroid-stimulating immunoglobulin TSS toxic shock syndrome TSST toxic shock syndrome toxin TTP thrombotic thrombocytopenic purpura TV tidal volume TXA thromboxane UA urinalysis UCV Underground Clinical Vignettes UDP uridine diphosphate UMN upper motor neuron URI upper respiratory infection USDA United States Department of Agriculture Abbreviation Meaning USIA United States Information Agency USMLE United States Medical Licensing Examination UTI urinary tract infection UV ultraviolet VA ventral anterior, Veterans Administration Val valine VC vital capacity Vd volume of distribution VDRL Venereal Disease Research Laboratory VEGF vascular endothelial growth factor VF ventricular fibrillation VIP vasoactive intestinal peptide VIPoma vasoactive intestinal polypeptide- secreting tumor VLDL very low density lipoprotein VMA vanillylmandelic acid VPL ventral posterior nucleus, lateral VPM ventral posterior nucleus, medial VPN ventral posterior nucleus VQ ventilationperfusion ratio VSD ventricular septal defect VZV varicella-zoster virus WBC white blood cell XR X-linked recessive пп512 пABBREVIATIONS AND SYMBOLS Page 405 Page 556 Page 619 Page 84 Page 366 Page 178 Page 170 Atropine sulphate EUROPEAN PHARMACOPOEIA 6. Schnabel, L.
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