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The working assumption is that these pathways are selectively activated or inactivated in tumors such that in- terventions specifically targeting these pathways should have a limited impact on normal tissues. 1,3-dicyclohexylurea. 12 Metastatic deposits from primary pancreatic adenocarcinoma occur early in the course of the disease, and 80 of patients already have nodal dis- ease or distant metastases in the lungs, liver or bone by the time the diagnosis is made. ПппппппппппппппSCHA_22-Tile. , Hawkins, R.
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